Ramipril Tablet – Uses, Dosage, Benefits | ACE Inhibitor for BP & Heart

Therapeutic Indication

Hypertension (High Blood Pressure)

Congestive Heart Failure

Post Myocardial Infarction

Diabetic Nephropathy

Cardiovascular Risk Reduction

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Ramipril

Tablet

Ramipril Tablet is an angiotensin-converting enzyme (ACE) inhibitor used to manage hypertension, heart failure, and to reduce the risk of cardiovascular events. It helps relax blood vessels, improve blood flow, and decrease the workload on the heart.

Speciality	Cardiology \| Nephrology \| General Medicine
Tags	ACE Inhibitor \| Hypertension \| Heart Failure \| Kidney Protection \| BP Control
Strength	5 mg
Packing Size	10 Tablets

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Mechanism

Ramipril inhibits the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This leads to vasodilation, reduced aldosterone secretion, decreased sodium retention, and ultimately lowers blood pressure while protecting the heart and kidneys.

Pharmacokinetics

Absorption: Rapidly absorbed after oral administration
Bioavailability: ~50–60%
Distribution: Converted to active metabolite (ramiprilat)
Metabolism: Hepatic metabolism to ramiprilat
Elimination: Excreted via urine and feces
Half-life: 13–17 hours (ramiprilat)

Side Effects

Dry cough
Dizziness
Hypotension
Hyperkalemia
Fatigue

Contraindication

History of angioedema
Pregnancy
Severe renal artery stenosis
Hypersensitivity to ACE inhibitors

Interaction

Potassium supplements & potassium-sparing diuretics
NSAIDs (may reduce effect)
Diuretics (increase hypotension risk)
Lithium (increased toxicity risk)

Warning and Precautions

Monitor renal function and potassium levels
Use cautiously in renal impairment
Avoid during pregnancy
Start with low dose in elderly patients

Ramipril Tablets